GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs703842 | 1 | rs6581155 | chr12:58178162 | TSFM | chr12:58176536-58191367:+ | -0.56 | -19.03 | 1.55E-60 | Multiple sclerosis |
| THCA | cis | rs703842 | 1 | rs6581155 | chr12:58178162 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.23 | -4.65 | 4.28E-6 | Multiple sclerosis |
| THCA | cis | rs7078219 | 1 | rs6584278 | chr10:101278099 | NKX2-3 | chr10:101292690-101296278:+ | -0.31 | -5.5 | 6.21E-8 | Dental caries |
| THCA | cis | rs975752 | 1 | rs6584347 | chr10:101906963 | BLOC1S2 | chr10:102033713-102046439:- | -0.43 | -6.42 | 3.31E-10 | Schizophrenia |
| THCA | cis | rs975752 | 1 | rs6584347 | chr10:101906963 | CWF19L1 | chr10:101992055-102027437:- | -0.43 | -5.27 | 2.04E-7 | Schizophrenia |
| THCA | cis | rs11190604 | 1 | rs6584379 | chr10:102224490 | SEC31B | chr10:102246403-102289636:- | -0.3 | -10.24 | 2.25E-22 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs11190604 | 1 | rs6584383 | chr10:102303065 | SEC31B | chr10:102246403-102289636:- | -0.28 | -8.89 | 1.29E-17 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs4509693 | 1 | rs6584392 | chr10:102497166 | FBXW4 | chr10:103370422-103454743:- | -0.17 | -3.35 | 0.000867 | Alzheimer's disease |
| THCA | cis | rs6585827 | 1 | rs6585827 | chr10:124165615 | PLEKHA1 | chr10:124134220-124191866:+ | -0.21 | -5.73 | 1.78E-8 | Height |
| THCA | cis | rs7226229 | 1 | rs6587109 | chr17:20917818 | USP22 | chr17:20902908-20947073:- | -0.18 | -3.75 | 0.000201 | Blood trace element (Se levels) |
| THCA | cis | rs7112513 | 1 | rs6589575 | chr11:116733310 | PCSK7 | chr11:117075789-117102811:- | -0.3 | -5.14 | 4.02E-7 | Protein quantitative trait loci |
| THCA | cis | rs7112513 | 1 | rs6589576 | chr11:116735788 | PCSK7 | chr11:117075789-117102811:- | 0.26 | 4.53 | 7.32E-6 | Protein quantitative trait loci |
| THCA | cis | rs7112513 | 1 | rs6589589 | chr11:116932428 | PCSK7 | chr11:117075789-117102811:- | -0.29 | -5.03 | 6.88E-7 | Protein quantitative trait loci |
| THCA | cis | rs6592284 | 1 | rs6592284 | chr11:86055901 | C11orf73 | chr11:86013253-86056984:+ | 0.23 | 5.36 | 1.33E-7 | Cognitive performance |
| THCA | cis | rs6592284 | 1 | rs6592284 | chr11:86055901 | CCDC81 | chr11:86085778-86134150:+ | -0.22 | -3.86 | 0.000129 | Cognitive performance |